What Is Ankylosing Spondylitis (AS)?
Arthritis is a complex family of musculoskeletal disorders consisting of more than 100 different diseases or conditions that destroy joints, bones, muscles, cartilage and other connective tissues, hampering or halting physical movement. Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily affects the sacroiliac joints (where the spine attaches to the pelvis), spine, and hip joints. Ankylosing is a term meaning stiff or rigid and spondylitis means inflammation of the spine.
Enthesitis (inflammation of the place where ligaments and muscles attach to bones) accounts for much of the pain and stiffness of AS. This inflammation eventually can lead to bony fusion of the joints (where the fibrous ligaments transform to bone, and the joint permanently grows together).
Other joints can also develop synovitis (inflammation of the lining of the joint), with lower limb joints more commonly involved than upper-limb joints.
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